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Research Depth We sorted evidence into four tiers and placed every compound on one: Human randomized controlled trials with energy-relevant endpoints Human data on related endpoints, or early-phase and small studies Animal models Cell and in vitro work only Mechanistic Evidence Some have a clean path from action to energy pathway, NAD+ being the clearest example since its role in cellular energy is textbook biochemistry

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Table 1 provides an overview of the different chemical addition strategies