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Several small molecules identified in a drug screening appear to converge on metal ion chelation and/or inhibition of NF-κB and Akt/GSK3β pro-survival signaling pathways To get further insights into the molecular mechanisms involved in the regulation of CBS activity, we screened a set of 2,932 small molecules from the National Cancer Institute, consisting in diverse chemical scaffolds, including natural products and approved oncology drugs

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doi: 10.3969/j.issn.1005-9202.2018.09.057 13