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When mitochondrial protein folding stress persists, the mitochondrial unfolded protein response (UPRmt) may be triggered to enhance the expression of mitochondrial chaperones, proteases, and antioxidant-related genes, thereby helping to restore mitochondrial protein homeostasis (126)

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Direct measurements of proliferation by BrdU incorporation indicated a 78.1% decrease in BrdU incorporation in spheres growing in the absence (w/o growth factors) compared to the presence (solvent control) of growth factors (Figure 2C)