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EGCG demonstrated favorable effects on inflammatory and fibrotic changes in other animal models, e.g., in irradiation-induced fibrosis where anti-oxidant effects were in relation with activation of Nrf2 and associated antioxidant enzymes HO-1 and NQO-1 [123], or in cyclophosphamide- [288] and paraquat-induced induced models of pulmonary fibrosis [289]
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