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The receptor for HGF, called c-Met, sits on the surface of many cell types including neurons

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An interesting observation is that methionine depletion has inhibited the EZH2 expression significantly in CpG/IFN-α/BCR simulated B cells (105), and the methionine level determines the mTORC1 activation as we described above, suggesting that mTORC1 is the mid-mediator of methionine induced EZH2 expression