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Further exploration with another photoactive CORM, [Mn(CO) 3 Br(μ-bpcpd)] 2 (MnCORM) with lung, cervical, breast, and colon cancer cell lines revealed that apoptosis was induced through the intrinsic pathway by increasing ROS, resulting in the loss of mitochondrial membrane potential and corresponding increases in Bax, cytochrome c release, caspases −3 and −9, and a decrease in anti-apoptotic Bcl-2 levels (P, D et al