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TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2
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Inhibition of pyrimidine synthesis and HIF through leflunomide and digoxin respectively, would disable DNA synthesis as well as adaptation to hypoxia, thereby rendering pancreatic cancer sensitive to presumably any therapeutic stress (sensitizing PDAC tumors to gemcitabine) [60]
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