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We review the above three methods because: we believe that PET scanning using TSPO-binding radioligand is the best-available and most direct option for studies of neuroinflammation but that methods must be optimized, MRS is much more widely available than PET with TSPO-binding radioligand and has good potential for a less expensive and invasive option for indirectly imaging neuroinflammation, and studies commonly seek to find a distinct peripheral circulating cytokine “profile” in ME/CFS, and we offer critiques of current approaches