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Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood
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In a CV outcomes trial, 3,327 (50%) of MOUNJARO-treated patients were 65 years of age or older, and 705 (11%) of MOUNJARO-treated patients were 75 years of age or older at baseline [see Clinical Studies (14.6)]
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