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In terms of antioxidant effects, flavonoids activate the Nrf2/antioxidant response element (ARE) pathway, upregulating the expression and activity of antioxidant substances such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while reducing the levels of malondialdehyde (MDA), lipid peroxides (LPO), and excess nitric oxide (NO), thereby alleviating intestinal oxidative damage (Hu et al., 2022
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