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15.17 Chemical Properties of Amides: Hydrolysis | The Basics of General, Organic, and Biological Chemistry
The comprehensive SAR studies led to the identification of compound 51 (Figure 10), which exhibited superior pharmacokinetic parameters in Sprague–Dawley (SD) rats, characterized by high oral bioavailability (F = 89.9%) and an appropriate half-life (T 1/2 = 2.0 h)
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