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OXIDATIVE STRESS AND FIBROSIS OF THE LUNG, LIVER AND KIDNEY Several reports described the contribution of oxidative stress to the pathogenesis of fibrosis in organs such as the lung, the liver and the kidney
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Metformin, the most commonly prescribed drug for diabetes, may also increase insulin sensitivity in peripheral tissues during fasting by reducing HGP, which is considered to be mediated by the promotion of mitochondrial activity or the inhibition of glucagon signaling through AMPK activation [160,161]
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