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Endogenous tyrosinase-catalyzed therapeutics | Nature Communications

The durability of vaccine protection is another key area that requires a better understanding of the fundamentals of immune memory, a key question being “ how can we limit the acute contraction of the adaptive immune response after prophylactic vaccination and limit attrition of long-term memory , in particular for nAb titers in the blood?”

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Loss of SLC33A1 leads to GSSG accumulation and a hyperoxidizing ER environment, which impairs non-native disulfide resolution and causes misfolded protein accumulation