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This acidifies the tissue microenvironment, which can suppress T cell function and cytotoxicity, further impairing the antiviral immune response ( 3.3 Disruption of mitochondrial dynamics and quality control Mitochondria are highly dynamic organelles that undergo constant fission (division) and fusion (merging) to maintain a healthy network
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Specific concepts that we believe may be particularly noteworthy include: (1) Misfolding of innate CNS proteins, which then leads to their aggregation into potentially toxic oligomers or amyloids, leading to a toxic gain-of-function via numerous mechanisms including membrane disruption (Kandel et al., 2017
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