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Definition: High serum vitamin B12 is defined by a rate above 950 pg/ml (701pmol/l), which corresponds by biological standards, to the upper limit of biological normality

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This is achieved through downregulation of β-catenin transcription factor-7-like-2 (TCF7L2) mRNA and suppression of downstream Wnt/β-catenin signaling target genes, including Cyclin D1, c-Myc, Snail, Vimentin, matrix metalloproteinase 2 (MMP2), and MMP9, in human CRC cells ( 3.2 Effect of the Wnt/β-catenin signaling pathway on angiogenesis in CRC Angiogenesis is a critical process in the progression of tumor growth and metastasis