glutathione detectuib Multifunctional carbon dots for detection and Golgi imaging Glutathione reductase

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TB-500’s actin-sequestering function is most critical during the proliferative phase, when fibroblast migration and collagen deposition dominate

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For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of ∼10 mM, which is approximately ten times higher than that in normal cells ( In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance ( via the multidrug resistance associated proteins (MRPs) efflux pump ( 3 GSH-responsive and -exhausting metal nanomaterials 3.1 Inorganic nanomaterials Inorganic nanomaterials that have intrinsically unique physicochemical properties and can provide satisfactory functionality show enormous potential in biomedical applications, especially in cancer therapy ( 2 O 2 , realizing tumor-specific catalytic therapy with response to the TME featuring overexpressed GSH and H 2 O 2 ( 3 -PEG nanocages, which can serve as horseradish peroxidase-like and GSH peroxidase-like nanozymes for enhanced ROS-based therapy by exhaustion of GSH (Zhong et al., 2020)