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Under conditions of immune-inflammatory dysregulation, AKG further suppresses inflammatory responses by directly reducing the levels of multiple pro-inflammatory factors, including IL-6, IL-1β, and tumor necrosis factor-alpha (TNF-α) [12,47,48] , as well as IL-4, IL-25, IL-3, and thymic stromal lymphopoietin (TSLP) [49] , further highlighting its broad anti-inflammatory effects
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