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The study participants were hypertensive (clinic systolic/diastolic BP of 140-179/90-109 mmHg and 24-hour ambulatory systolic/diastolic BP ≥ 130/80 mmHg) patients enrolled in a randomized controlled trial and treated with amlodipine 5–10 mg or nifedipine gastrointestinal therapeutic system (GITS) 30–60 mg once daily

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But some adjust dosing based on: Subjective response: If a patient reports increased energy or reduced appetite on MIC injections, some providers increase the dose to 1 mL twice weekly or switch to a high-potency formulation