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The sorbitol (polyol) pathway is a two-step metabolic route converting glucose to fructose, acting as an alternative pathway during high blood sugar. It involves reducing glucose to sorbitol via aldose reductase (consuming
It is hypothesized that this increased gut permeability leads to a higher concentration of LPS in portal blood circulation, where LPS then binds to TLR4 and activates NF-κB, which in turn stimulates the expression of proinflammatory cytokines [39,91]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Donnellly R.F., Singh T.R.R., Morrow D.I.J., Woolfson A.D
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