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(ii) Activate immune dysregulation through PAR2/NF-κB and ERK1/2-Ets1 signaling pathways, promoting oral mucosal pathogenesis.) (Right Panel: Probiotic Intervention) Probiotics counter disease progression by: (i) Suppressing pro-inflammatory signaling (NF-κB, TNF, IL-17) to reduce inflammatory infiltration;(ii) Preserving epithelial barrier integrity via prevention of tight junction protein degradation (e.g., by reducing LPS burden)