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Skeletal muscle and aging A 2019 study by Neelakantan, Brightwell, Graber, and colleagues in Biochemical Pharmacology extended the same NNMT-inhibitor chemotype (referred to in the paper as "NNMTi," a quinolinium small molecule from the 5-Amino-1MQ family, dosed at 5 and 10 mg/kg) to a different tissue context: aged skeletal muscle in 24-month-old mice

Laboratory Chemical

Size:3.4 fl.oz

Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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