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Specifically, there were the liver and lung congestion with intralveolar hemorrhage and pyknotic hepatocyte nuclei, marked congestion in heart tissue, within myocardium and large coronary branches, hyaline tubular cylinders, cell degeneration of proximal and distal tubule with cytoplasmic vacuolization in kidney after both in short-term (15 min ligation time, and period thereafter) and in long-term (24 h, 48 h)

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The development of this long-acting analogue is extensively documented in the medicinal-chemistry literature Kruse et al., 2021