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These two compounds 41 and 43 possess good biochemical properties and satisfy Lipinski’s “rule of five” and exhibited a substantial inhibitory effect on melanin synthesis in B16 cells

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(1) In healthy people, after oral administration of 64 mEq of potassium chloride solution, the time to peak ( T max ) was 1.0 h and the increase in peak concentration ( C max ) was 1.7 meq/L ( T max was 1.0 h and the increase in C max was 0.8 meq/L after potassium supplementation of 50 mEq ( T max and C max