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Activated immune cells release cytokines (e.g., IL-6, TNF-α) and ROS, further disrupting iron homeostasis (e.g., via IRP2 activation and ferritinophagy) and promoting lipid remodeling (e.g., through ACSL4 upregulation), thereby amplifying ferroptosis
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Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and α-synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain
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