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The research indicates that the absence of NOL1/NOP2/Sun domain family, member 5 (NSUN5) leads to a reduction in the levels of 5-methylcytosine in ferritin heavy chain 1(FTH1)/ferritin light chain (FTL) RNA, which results in increased iron concentration in BMSCs, downregulation of GPX4, and accumulation of ROS and lipid peroxidation products (45)