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By dosage, the mean changes were: 500 mcg: ∼127% 750 mcg: ∼176% (single study) 1,000 mcg: ∼280% 1,500 mcg: ∼310% 2000 mcg: ∼260% 5,000 mcg: ∼62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

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In the course of UC, this oxidative/antioxidative imbalance mainly involves the following mechanisms: infiltration of intrinsic immune cells neutrophils and macrophages into the inflamed intestine, which releases large amounts of ROS through the NADPH oxidase (NOX)-dependent pathway