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After APAP overdose, cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), and chemokines, such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 2 (MIP-2), were detected in the plasma of animals and patients

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A large share of the human outcome data circulating under the Epitalon name — including the frequently cited mortality findings in older adults — comes from trials that administered epithalamin, the bovine extract, not the synthetic tetrapeptide