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Science Review: Sulforaphane | Metagenics Institute
FIGURE 4 Novel drug modalities for NRF2 activation Up to date, the only NRF2 activators in clinical use are DMF for MS (Rosito et al., 2020), and more recently Omaveloxolone, a semisynthetic terpenoid with potent NRF2-activating effects gained FDA approval in Februrary 2023 for the treatment of Friederich’s ataxia ( However, most NRF2 activators are of electrophilic nature and exhibit unpredictable poly-pharmacology
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