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Acknowledgements The work is financially supported by National Natural Science Foundation of China (22022411 to Z.J.Z., 82003554 to H.J.), Key R&D Program of Zhejiang province (2022C03015 to J.Z.), Natural Science Foundation of Shanghai (19ZR1410600 to J.Z.), National Key R&D Program of China (2022YFC3400702 to Z.J.Z.), Shanghai Municipal Science and Technology Major Project (2019SHZDZX02 to Z.J.Z.), Shanghai Key Laboratory of Aging Studies (19DZ2260400 to Z.J.Z.), and Scientific project of Shanghai Municipal Health Commission (201940151 to H.J.)