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At the translational level, GLS1 inhibition reduced Th17 differentiation of CD4 + T cells in SLE patients in vitro ( + T cells ( + T cells, and GLS2 reduces ROS levels and promotes the ability of CD4 + T cells to produce IL-2 by demethylating the IL-2 gene ( + T cells ( 4.2 Psoriasis Psoriasis occurs as a result of a complex interaction between genetic and environmental factors causing DC activation to produce related cytokines such as IFN-α, IFN-β, IL-12, IL-23, IL-6, and TNF-α
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Gene expression analysis using RNA-seq The quantification of mRNA from the RNA-seq FASTQ files was performed using Salmon, for both Day 1 (Baseline, BL) and Day 120 visits, from 18 Placebo, 18 UA 500 mg and 21 UA 1000 mg samples
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