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In this case, mt-ROS probably increases its concentration inside the cell, promoting a higher level of release of cytochrome C due to ETC activity, causing apoptosis and worsening oxidative stress [247,248,249,250,251]
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Because the original definition of ferroptosis did not include mitochondrial dysfunction and ATP depletion [13] , which is a hallmark of APAP-induced cell death with or without LPO, we decided to call it ferroptosis-like cell death to distinguish it from the original definition
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