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In the brains of Alzheimer’s disease (AD) patients, pathological features such as reduced mitochondrial membrane potential (ΔΨm), accumulation of mitochondrial peroxides, aberrant opening of the mitochondrial permeability transition pore (mPTP), and mitochondrial iron (mFe) overload are commonly observed—each closely linked to ferroptosis induction (Chen et al., 2023
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Circadian entrainment of hypothalamic–pituitary-gonadal (HPG) signaling further supports synchronization of gonadotropin release and follicular maturation, reinforcing its reproductive benefits (201)
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