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The STEP-9 osteoarthritis trial data — where semaglutide produced −41.7 points on the WOMAC pain/function scale versus −27.5 for placebo — represents a clinically significant improvement in quality of life for people who are currently managing joint pain with ibuprofen and cortisone shots.11 "GLP-1 therapies are emerging as dual-action agents that not only improve cardiometabolic risk factors but may also influence disease activity and long-term outcomes for patients with autoimmune and inflammatory conditions." — Dr